Glossary

Biochemistry, molecular genetics, and biology glossary terms for Companion Sites.

wortmannin

Wortmannin is a fungal metabolite that is a specific inhibitor of PI3Ks, though it can also inhibit mTOR, DNA-PK, some phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK).

Because Akt is located downstream of PI3K, Akt functions as part of a wortmannin-sensitive signaling pathway.

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