Biochemistry, molecular genetics, and biology glossary terms for Companion Sites.

receptor tyrosine kinases

Receptor tyrosine kinases (RTKs) are involved in signal transduction, and process a variety of environmental and intercellular cues. By contrast, protein tyrosine kinases (PTKs) are non-receptor, cytoplasmic enzymes that catalyze the phosphorylation of tyrosine residues.

Binding of ligands to RTKs leads to phosphorylation of tyrosine residues, creating phosphotyrosine docking sites for proteins that transduce signals within the cell. As central components of cell signaling networks, RTKs play crucial play crucial roles in physiological processes, such as embryogenesis, differentiation, neurite outgrowth, cell proliferation, anti-apoptotic signaling and death of cells (apoptosis).

 Receptor Tyrosine Kinases(RTK)

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