Biochemistry, molecular genetics, and biology glossary terms for Companion Sites.


Spliceosomes are complex ribonuclear machines in eukaryotes that remove (splice out) the non-coding introns from primary transcript, precursor mRNA (pre-mRNA or hnRNA). Almost all eukaryotic protein coding genomes contain non-coding intervening sequences called introns.

Spliceosomes are variably composed of as many as 300 distinct proteins and five RNAs, making them among the most complex macromolecular machines known. Small RNA-protein complexes called small nuclear ribonucleoproteins (snRNPs, pronounced 'snurps') are essential components of the spliceosome.

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