Glossary

Biochemistry, molecular genetics, and biology glossary terms for Companion Sites.

serine/threonine kinases

Serine/threonine kinases phosporylate serine and threonine residues in target proteins. Specific protein kinases transfer a phosphate group from a donor such as ATP to amino acid acceptors in proteins, while protein phosphatases remove the phosphate groups that have been attached by protein kinases.

Several serine/threonine kinases function in signal transduction pathways, associated with receptors of the TGF-β superfamily that employ intrinsic serine/threonine kinase (phosporylating) activity to signal through the Smad family of proteins.

The signaling pathways utilized by the TGF-β, activin, and BMP receptors are different than those for receptor tyrosine kinases (RTKs) or receptor proteins associated with intracellular protein tyrosine kinases (PTKs).

cAMP-dependent protein kinase cyclin-dependent kinasesAkt ~ ERKsMAPKsMEKsmitogen activated protein kinasesMPFM-phase promoting factormTORPDK1PTENPIKKPI3KPKAPKBPKCsprotein kinasesRaf .

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