tumorigenic viruses

Viral carcinogenesis (malignant transformation) is an accidental, cancer causing side effect of viral replication strategies.

Viruses are typically not complete carcinogens, with the known human cancer viruses displaying different roles in transformation. Tumorigenic viruses are subdivided according to the nucleic acid of their genome. Transforming retroviruses carry oncogenes originally derived from cellular genes that are involved in mitogenic signaling and growth regulation. DNA tumor viruses encode viral oncogenes that are essential for viral replication and cell transformation; viral oncoproteins complex with cellular proteins to stimulate cell-cycle progression.

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