tumor suppressors

Tumor suppressor genes encode proteins that reduce the risk that a eukaryotic cell line will become tumorigenic (cancerous). Tumor suppressor proteins act as cell-cycle repressors and/or promoters of apoptosis.

When tumor suppressor proteins are sequestered away from their normal functional locations within the cell by retroviral tumor antigens, the loss of their normal suppressor functions results in cellular transformation. Because a single normal allele will express the wild-type suppressor protein, most tumor suppressor genes are recessive, meaning that both alleles must be defective for the cell to be susceptible to tumor development.

: APC : CBFA2T3 : Hsp90 : MDM2 : p53: PTEN : TP53 : Wnt :

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